In addition to depression, doctors can prescribe Cymbalta to treat anxiety that lasts for at least six months, pain from diabetic nerve damage, fibromyalgia, and long-term muscle or bone pain. Summary. Bone loss is found among people who take Cymbalta, especially for people who are female, 40-49 old , have been taking the drug for 1 - 6 months, also take medication Zometa, and have Multiple myeloma. Find patient medical information for Cymbalta Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Can Cymbalta cause Bone Loss? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. - Page 2 In one study, older women who took SSRI antidepressants showed a 60% acceleration in bone loss, compared with women who did not take antidepressants, researcher Susan J. Diem, MD, MPH, tells WebMD. Can Cymbalta cause Bone Loss? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Note: This document contains side effect information about duloxetine. Some of the dosage forms listed on this page may not apply to the brand name Cymbalta. Cymbalta (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Summary. Tooth loss is found among people who take Cymbalta, especially for people who are female, 60+ old , have been taking the drug for 2 - 5 years, also take medication Zometa, and have Pain. Cymbalta (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for treating depression, anxiety disorder, and pain associated with diabetic peripheral neuropathy or fibromyalgia.